Synthesis of tetrazole ribonucleosides and their evaluation as antiviral agents. 2. 5-Amino-1-(.beta.-D-ribofuranosyl)-1H-tetrazole and 5-amino-2-(.beta.-D-ribofuranosyl)-2H-tetrazole
- 1 August 1976
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 19 (8) , 1017-1020
- https://doi.org/10.1021/jm00230a008
Abstract
Synthesis of 5-amino-1-(.beta.-D-ribofuranosyl)-1H-tetrazole and 5-amino-2-(.beta.-D-ribofuranosyl)-2H-tetrazole is described. X-Ray crystallography was first used to establish the stereochemical configuration of the 2 isomers. By conducting 13C NMR analysis on these isomers with known structures, i.e., N1.beta. and N2.beta., a correlation is developed for determining the N-ribosyl attachment site of tetrazole ribonucleosides. Results are also presented on antiviral testing of these synthetic 5-aminotetrazole ribonucleosides against influenza A2/Asian/J305 virus infection in mice.This publication has 0 references indexed in Scilit: