Role of 5-hydroxytryptamine in prostaglandin E1-induced potentiation of hexobarbitone hypnosis in albino rats
- 1 July 1976
- journal article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 32 (7) , 907-908
- https://doi.org/10.1007/bf02003761
Abstract
PGE1 potentiated, while diclofenac, a prostaglandin synthesis inhibitor, antagonized hexobarbitone hypnosis in rats. PGE1-induced potentiation of hexobarbitone sleep was inhibited by a 5HT synthesis inhibitor and by a 5HT receptor blocker, suggesting that this potentiation is 5HT mediated.Keywords
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