Diterpene Metabolites from Two Chemotypes of the Marine Sponge Myrmekioderma styx
- 1 October 1992
- journal article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 55 (10) , 1421-1429
- https://doi.org/10.1021/np50088a006
Abstract
Three apparent chemotypes of the marine sponge Myrmekioderma styx exist. An acyclic diterpene, styxenol A [1], has been isolated from the shallow water chemotype, while three tricarbocyclic diterpenes 3, 6, and 7 have been isolated from the deep chemotype. The structures were elucidated based on spectral methods including homo- and hetero-nuclear 2D nmr experiments. Compounds 1, 3, and 6 exhibit moderate cytotoxicity against the P-388 murine leukemia cell line and the A549 human lung tumor cell line.Keywords
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