Expanded Scope in Ethylene−Alkyne Cross-Metathesis: Coordinating Heteroatom Functionality at the Propargylic Position
- 24 June 2000
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 2 (15) , 2271-2274
- https://doi.org/10.1021/ol006035l
Abstract
The Grubbs 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene-substituted ruthenium complex 1 catalyzed ethylene−alkyne cross-metathesis and was shown to tolerate free hydroxyl groups and coordinating functionality at the propargylic and homopropargylic positions. Hindered and enantiomerically enriched 1-substituted alkynes also react efficiently under the reported conditions.Keywords
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