An Extracorporeal Device for Hepatic Coma
- 2 February 1963
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 183 (5) , 350-351
- https://doi.org/10.1001/jama.1963.63700050020013e
Abstract
IN THIS LABORATORY in 1958,1 blood was first passed over ion exchange resins to lower hyperammonemia. It was noted that a column of the cation exchange resin Dowex 50 × 8 used by Walther2 to decalcify blood would also remove ammonium. Laboratory studies on dogs with surgically induced, acute, hepatic ischemia showed this to be an effective and safe in vivo method of lowering blood ammonia. It was theorized that perfusion of blood over ion exchange resins might be a satisfactory method of treating the hyperammonemia of patients in hepatic coma. The first columns contained 50 gm Dowex 50 × 8, a cation exchange resin in the sodium cycle, in 12 cm × 3.5 cm hemorepellent vinylite plastic containers. Two such columns, used in parallel, were connected to the radial artery and antecubital vein. Blood flowed through the columns and returned to the vein under the forceKeywords
This publication has 0 references indexed in Scilit: