Neuropsychological diagnostic profiles of children who received CNS treatment for acute lymphoblastic leukemia: The systemic approach to assessment
- 1 January 1992
- journal article
- other
- Published by Taylor & Francis in Developmental Neuropsychology
- Vol. 8 (1) , 1-28
- https://doi.org/10.1080/87565649209540512
Abstract
A systemic developmental neuropsychological approach (Bernstein & Waber, 1990) was applied in a controlled fashion to evaluate its reliability and validity. Specifically, we examined the impact of central nervous system (CNS) treatment on behavioral development of children treated for acute lymphoblastic leukemia (ALL). A blind structured clinical rating procedure yielded severity ratings and neuropsychological diagnoses for 49 ALL patients and 15 Wilm's tumor (WT) patients. The ALL patients were more severely affected than the WT patients and females more affected than males. Neuropsychological diagnostic profiles were systematically related to age at CNS treatment: Children treated before 36 months of age exhibited inefficiencies of right‐hemisphere brain systems; those treated at older ages showed left‐hemisphere related inefficiencies. The findings are discussed in relation to processes of human postnatal neurobehavioral development, as well as to the status of the systemic approach.Keywords
This publication has 49 references indexed in Scilit:
- The syndrome of nonverbal learning disabilities: Developmental manifestations in neurological disease, disorder, and dysfunctionThe Clinical Neuropsychologist, 1988
- When diagnostic agreement is high, but reliability is low: Some paradoxes occurring in joint independent neuropsychology assessmentsJournal of Clinical and Experimental Neuropsychology, 1988
- Neurobehavioral effects of central nervous system prophylactic treatment of cancer in childrenJournal of Clinical and Experimental Neuropsychology, 1988
- Assessing frontal lobe functioning in children: Views from developmental psychologyDevelopmental Neuropsychology, 1988
- Hormonal state affects recovery from frontal cortex lesions in adult female ratsBehavioral and Neural Biology, 1987
- Syndrome of nonverbal learning disabilities: The final common pathway of white-matter disease/dysfunction?The Clinical Neuropsychologist, 1987
- Long-term neuropsychologic sequelae of childhood leukemia: Correlation with CT brain scan abnormalitiesThe Journal of Pediatrics, 1985
- Neuromaturation and behavior development: The case of childhood lead poisoning.Developmental Psychology, 1984
- Abnormal CT Scans of the Brain in Asymptomatic Children with Acute Lymphocytic Leukemia after Prophylactic Treatment of the Central Nervous System with Radiation and Intrathecal ChemotherapyNew England Journal of Medicine, 1978
- Rapid ‘automatized’ naming (R.A.N.): Dyslexia differentiated from other learning disabilitiesNeuropsychologia, 1976