Phase II trial of fludarabine phosphate in advanced renal cell carcinoma: An Illinois Cancer Council study
- 1 July 1989
- journal article
- research article
- Published by Springer Nature in Investigational New Drugs
- Vol. 7 (2-3) , 251-253
- https://doi.org/10.1007/bf00170869
Abstract
Fludarabine Phosphate (FP), the 2-fluoro, 5′ phosphate derivative of adenosine arabinoside (ara-A), was studied in 18 patients with advanced renal cell carcinoma. These patients had measurable disease and had not received chemotherapy. FP was administered at a loading dose of 20 mg/m2 followed by a 48-hour infusion at 30 mg/m2/day given every 21 days. There were no complete or partial responses seen. Toxicity was mainly hematologic, with leukopenia most commonly observed. FP given in this manner had no activity in advanced renal cell carcinoma.Keywords
This publication has 4 references indexed in Scilit:
- PHASE-I CLINICAL INVESTIGATION OF 9-BETA-D-ARABINOFURANOSYL-2-FLUOROADENINE 5'-MONOPHOSPHATE (NSC 312887), A NEW PURINE ANTIMETABOLITE1984
- Toxicity and response criteria of the Eastern Cooperative Oncology GroupAmerican Journal of Clinical Oncology, 1982
- COMPARISON OF THE TOXICITY AND METABOLISM OF 9-BETA-D-ARABINOFURANOSYL-2-FLUOROADENINE AND 9-BETA-D-ARABINOFURANOSYLADENINE IN HUMAN-LYMPHOBLASTOID CELLS1980