Studies on Lysergic Acid Diethylamide and Related Compounds. IV. Syntheses of Various Amide Derivatives of Norlysergic Acid and Related Compounds

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Abstract
In order to study the microbial transformation of lysergic acid diethylamide, several amide derivatives of norlysergic acid were prepared from the corresponding amide derivatives of Iysergic acid by treatment with cyanogen bromide followed by hydrolysis with 1.4% HCl-dioxan at 100°. N6-Allyl-, -propyl-, and-ethyl-norlysergic acid diethylamide were also prepared to examine their pharmacological activities.