Glutathione S-Transferases and Prevention of Cellular Free Radical Damage
- 1 January 1998
- journal article
- research article
- Published by Taylor & Francis in Free Radical Research
- Vol. 28 (6) , 647-658
- https://doi.org/10.3109/10715769809065820
Abstract
This paper describes the intervention of glutathione-dependent enzymes, in particular the glutathione S-transferases (GSTs), in both the detoxication of electrophilic decomposition products resulting from the attack of oxygen radicals on lipids and DNA; and the prevention of oxygen toxicity generated by redox cycling catecholamine derivatives. The continuing growth of our knowledge of the glutathione S-transf erase polygene family is described in terms of the increase in members of known gene families, the discovery of new ones and our increasing knowledge of their activities towards endogenous substrates.Keywords
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