Fifty years of amanitin
- 1 December 1991
- journal article
- review article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 47 (11-12) , 1186-1193
- https://doi.org/10.1007/bf01918382
Abstract
Pharmacokinetic studies have provided new insights into humanAmanita poisoning, but it appears to be impossible to treat this intoxication by immunotherapy. New synthetic analogs have revealed structure-activity relationships that were unknown so far. The main toxin, α-amanitin, is in constant use as a tool in molecular biology and in biological research. First experiments have been reported in which amanitin bound to polymers could be internalized into tumor cells via a receptor-mediated endocytosis.Keywords
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