Mechanism of renal distribution of aminoglycoside antibiotics.

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Abstract
The renal accumulation of dibekacin, an aminoglycoside antibiotic, was pharmacokinetically analyzed and the mechanism of the renal accumulation of the antibiotic was investigated. The remaining amounts of dibekacin in the rabbit kidneys were adequately expressed by the biexponential equation. There was no possibility of a covalent bond between dibekacin and the renal tissue components. The renal accumulation of aminoglycoside antibiotics was explained in terms of the 2 successive processes, renal tubular reabsorption and electrostatic interaction between the antibiotics and the tissue components. The antibiotics were reabsorbed at the renal tubules and transported into renal tubular epithelial cells and bound to the tissue components by electrostatic force. The electrostatic interaction is important in increasing the acute toxicities of aminoglycoside antibiotics.