New Indolopyridoquinazoline, Benzo[c]phenanthridines and Cytotoxic Constituents fromZanthoxylum integrifoliolum
- 1 May 2005
- journal article
- research article
- Published by Georg Thieme Verlag KG in Planta Medica
- Vol. 71 (5) , 470-475
- https://doi.org/10.1055/s-2005-864144
Abstract
Three new alkaloids, 7,8-dehydro-1-methoxyrutaecarpine, isodecarine, and 8-demethyloxychelerythrine, together with sixteen known compounds, norchelerythrine, oxychelerythrine, decarine, dihydrocherythrinylacetaldehyde, 6-acetonyldihydrochelerythrine, rutaecarpine, 1-hydroxyrutaecarpine, γ-fagarine, skimmianine, (-)-matairesinol, (-)-isoarctigenin, (+)-epipinoresinol, d-sesamin, lupeol, canthin-6-one, and arnottianamide have been isolated from the root bark of Zanthoxylum integrifoliolum. The structures of these new compounds were determined through spectral analyses. Among the isolates, 7,8-dehydro-1-methoxyrutaecarpine, norchelerythrine, oxychelerythrine, dihydrocherythrinylacetaldehyde, 6-acetonyldihydrochelerythrine, 1-hydroxyrutaecarpine, γ-fagarine, skimmianine, (-)-matairesinol, and canthin-6-one exhibited cytotoxicities (ED50 values < 4 μg/mL) against P-388 or HT-29 cell lines in vitro.Keywords
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