Effect of Topical Cyclosporine Rinse on Oral Lichen Planus

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Abstract
The double-blind, vehicle-controlled, single-crossover study by Eisen et al. (Aug. 2, 1990, issue)1 demonstrated marked improvement in 16 patients with oral lichen planus treated with topical cyclosporine rinse in a volume of 5 ml (100 mg per milliliter), taken three times daily. The high dose of cyclosporine used in that study is prohibitively costly for use in clinical practice. The authors suggest that the efficacy of a lower dose of topical cyclosporine should be tested.