Vasculitis in cytomegalovirus infection

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Abstract
A 7-yr-old girl had fever, arthralgia and a mild cutaneous vasculitis with papules, nodules and livedo. A biopsy specimen of a papule showed lymphocytic small-vessel vasculitis, with some atypical lymphocytic nuclei. Splenomegaly developed and results of subsequent studies supported a diagnosis of cytomegalovirus (CMV) infection with atypical peripheral blood lymphocytes and a characteristic pattern of complement-fixing antibodies to CMV antigen. The CMV mononucleosis syndrome is rarely reported in children and cutaneous manifestations are usually rubelliform. Distinctive cutaneous pathologic characteristics were described previously only in neonates (blueberry muffin syndrome) and in immunosuppressed patients (viral inclusion bodies in endothelial cells).

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