Myoplasmic Calcium Changes Precede Metabolic and Clinical Signs of Porcine Malignant Hyperthermia

Publisher Website
Google Scholar
Abstract
Ration (Spo2), intraarterial blood pressure, rectal temperature, electrocardiogram (ECG), and train-of-four twitch measurements. Calcium-selective micro-electrodes were used to monitor changes in the concentration of free myoplasmic calcium ([Ca2+]i). The animals were studied in the resting state, during the development of the syndrome, and after treatment with dantrolene sodium. The increase in [Ca2+]i preceded the increase in ETco2 that preceded a decrease in Spo2 that preceded the classic first sign, tachycardia, and all preceded the increase in rectal temperature. Dantrolene reversed all of these physiologic changes in the same order of precedence as the increase. Address correspondence and reprint requests to John F. Ryan, MD, Department of Anesthesia, Massachusetts General Hospital, Boston, MA 02114. This work was supported by grants from CONICIT of Venezuela S1–1277, The Muscular Dystrophy Association, and a National Institutes of Health Center Grant GM 15904. Accepted for publication July 6,1994. © 1994 International Anesthesia Research Society...

This publication has 0 references indexed in Scilit: