Synthesis of (3R)-Amino-(2S)-Hydroxy Amino Acids for Inhibition of Methionine Aminopeptidase-1
- 1 December 1998
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 28 (23) , 4463-4470
- https://doi.org/10.1080/00397919808004481
Abstract
(3R)-amino-(2S)-hydroxy heptanoic acid (AHHpA) was synthesized via asymmetric aminohydroxylation and coupled with di-and tripeptides to form three compounds that inhibit MetAP-1 with IC50 values in the low micromolar range.Keywords
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