Tissue Lipid Quantification Using Narrow Bandwidth Magnetic Resonance Imaging with a Presaturation Pulse

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Abstract
Chemical-shift artifact occurs within tissues when band-like presaturation pulses are applied perpendicular to the frequency-encoding axis in narrow band-width magnetic resonance imaging. This phenomenon was used to quantify the lipid fraction in phantoms used to simulate tissue. Twenty phantoms with various lipid/water ratios were imaged on spin-echo sequence (repetition time/echo time, 2,000/20 msec) using a 1.5-T magnet. A narrow bandwidth that caused 6-mm chemical shift and a presaturation pulse 6-mm in width were used in the imagining. The lipid fraction values calculated from the resulting images were compared with values determined by a spectrometer. The image-derived values (LI) correlated strongly with the values determined by spectrometry (LS) (LI = 0.97 + 0.99 LS, r = .998). Chemical-shift artifact around the presaturation-applied areas should provide a simple and efficient method for the accurate quantification of tissue lipid fractions.

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