Preparation of selectively isotopically labelled β-hydroxypropionic acid
- 1 January 1986
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 3,p. 521-524
- https://doi.org/10.1039/p19860000521
Abstract
Two efficient three-step one-pot procedures for the synthesis of any combination of selectively isotopically labelled β-hydroxypropionic acids from relatively inexpensive labelled sodium acetate and gaseous formaldehyde or carbon dioxide have been developed. [1-14C]-, [2-14C]-, [2-14C,2-3H]-, [2-13C]-, and [2-13C,2-2H2]-β-hydroxypropionates have been prepared. The question of selective reduction of the intermediate malonate half esters is discussed and the general procedures are described.This publication has 0 references indexed in Scilit: