Successful Pregnancy despite Placental Cystine Crystals in a Woman with Nephropathic Cystinosis

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Abstract
CYSTINOSIS is an autosomal recessive disorder characterized by intracellular accumulation of cystine due to failure of the normal carrier-mediated system that transports cystine out of lysosomes.1 , 2 Intracellular cystine storage results in crystal formation in many tissues of the body. Clinical findings include growth retardation, photophobia, renal tubular Fanconi's syndrome, and renal glomerular failure, generally occurring by the age of 10 years.3 , 4 Before the era of renal transplantation,5 female patients with cystinosis did not survive past adolescence, and their reproductive capacity was unknown. We report a successful pregnancy in a woman with cystinosis and a renal allograft, along with the unusual . . .