The Mechanism of the [Cp2TiMe2]-Catalyzed Intermolecular Hydroamination of Alkynes

18 June 2001

journal article
Published by Wiley in Angewandte Chemie International Edition in English

Vol. 40 (12) , 2305-2308
https://doi.org/10.1002/1521-3773(20010618)40:12<2305::aid-anie2305>3.0.co;2-7

Abstract

A complex interplay between the catalyst concentration and the reaction rate exists, as shown by kinetic studies, for the [Cp2 TiMe2 ]-catalyzed intermolecular hydroamination of alkynes. The reason for this is a reversible dimerization of the catalytically active species [Eq. (1)]. L1 , L2 =Cp (cyclopentadienyl), Tol-NH (Tol=4-MeC6 H4 , tolyl).

Keywords

ALKYNES
AMINATION
HOMOGENEOUS CATALYSIS
METALLOCENES
TITANIUM