Proteolysis of mitochondria in reticulocytes during maturation is ubiquitin‐dependent and is accompanied by a high rate of ATP hydrolysis
- 28 January 1985
- journal article
- Published by Wiley in FEBS Letters
- Vol. 180 (2) , 249-252
- https://doi.org/10.1016/0014-5793(85)81080-2
Abstract
The ATP‐dependent breakdown of mitochondria‐containing stroma proceeds via the ubiquitin‐requiring pathway. The proteolysis is linked to a large ATP‐cleaved consumption amounting to 1 ATP per peptide bond or more. Proteins of mitochondria‐containing stroma are much better substrates of ATP‐ubiquitindependent proteolysis than heat‐denatured ones. Hemin suppresses both proteolysis and ATP hydrolysis.Keywords
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