Bactericidal effect against Escherichia coli of nalidixic acid and four structurally related compounds

1 July 1980

journal article
research article
Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy

Vol. 6 (4) , 535-542
https://doi.org/10.1093/jac/6.4.535

Abstract

The bactericidal action of nalidixic acid (NAL) and four structurally related compounds, oxolinic acid, 17563, 17607 and 17665, was examined in NAL-sensitive and -resistant strains of Escherichia coli. In the NAL-sensitive strain, NAL, 17563 and 17665 were bactericidal and 17607 was bacteriostatic, whereas in the NAL-resistant strain oxolinic acid was the only bactericidal compound. Cell death occurred at concentrations which inhibited DNA biosynthesis whilst having little effect on RNA and protein syntheses. Cell stasis occurred at concentrations which inhibited all three macromolecular processes.

Keywords

This publication has 1 reference indexed in Scilit:

Evidences for the Existence of Two Steps in DNA Replication Obtained in Toluene- Treated Escherichia coli
European Journal of Biochemistry, 1978