Role of Nonimmunized Macrophages in the Rejection of an Allotransplanted Lymphoma2

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Abstract
The ability of normal macrophages to assist immune cells in tumor killing was investigated. Peritoneal exudate cells, lymph node cells, and spleen cells were obtained from tumor-bearing hamsters with high levels of concomitant immunity. These cells were mixed with tumor cells and inoculated subcutaneously into either 1) normal, 2) thymectomized and irradiated, or 3) thymectomized, irradiated, bone-marrowgrafted syngeneic recipients. In some experiments normal peritoneal exudate cells were added to the mixtures. The results showed that irradiation of the recipients decreased tumor killing. Neither bone marrow transfusion nor the addition of peritoneal exudate cells restored this deficiency. The addition of peritoneal exudate cells did, however, produce skin lesions similar in many ways to those seen in delayed hypersensitivity reactions. It was concluded that tumor killing was most likely accomplished by direct action of immune cells on their target cells, whereas the skin lesion was due to an indirect effect of this interaction on normal macrophages. The decreased ability of adoptively immunized, thymectomized, irradiated hamsters to reject the tumor was considered due to the absence of active immunization.

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