THE EFFECTS OF LOCALLY APPLIED ESTROGEN ON THE PUBIC SYMPHYSIS AND KNEE JOINTc IN CASTRATED MICE1
- 1 April 1955
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 56 (4) , 461-470
- https://doi.org/10.1210/endo-56-4-461
Abstract
FOLLOWING puberty a sexual dimorphism of the pelvis develops in mice. At this time the medial ends of the pubic bones at the symphysis in the female undergo partial resorption (Gardner, 1936). During the first pregnancy the ventromedial part of the pubes is resorbed further and an interpubic ligament replaces the symphysial cartilage (Hall, 1947; Crelin, 1954a, 1954b). Similar changes occur in intact females and gonadectomized mice when estrogens are injected (Gardner, 1936; Crelin, 1954b, 1954c). Both the normal and induced pubic bone resorption follow a similar pattern. The cranio-dorsal surfaces of the medial ends of the pubes are affected first. The resorption then continues along the medial margin of each pubic bone in a caudo-lateral direction (Hall, 1950). As this process occurs in estrogen-injected mice all the other bones of the body undergo increased calcification (Gardner and Pfeiffer, 1938, 1943). The injected estrogen also induces a breakdown of the symphysial cartilage and its replacement by an interpubic ligament.Keywords
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