Estrogen Administered Neonatally Affects Adult Sexual Behavior in Male and Female Rats
- 10 April 1964
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 144 (3615) , 185-187
- https://doi.org/10.1126/science.144.3615.185
Abstract
The injection of 100 µg of estradiol benzoate into female rats 96 hours after birth abolished sexual receptivity in adulthood, even with estrogen and progesterone replacement after ovariectomy. The administration of testosterone propionate to these animals in adulthood elicited the full pattern of male sexual behavior. The same dose of estrogen given to male rats 96 hours after birth produced adults which were unable to achieve intromission, although they mounted as frequently as normal animals. Testosterone replacement after castration in adulthood reproduced this abnormal behavior.Keywords
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