THE EFFECTS OF LITHIUM IONS ON THE ANTIDIURETIC ACTION OF VASOPRESSIN IN THE RAT
Open Access
- 1 December 1975
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 55 (4) , 527-534
- https://doi.org/10.1111/j.1476-5381.1975.tb07428.x
Abstract
1 The effect of intravenous infusion of lithium, 2.56 μmol/min on the antidiuretic responses to antidiuretic hormone (ADH), adenosine triphosphate (ATP), 3′-5′ adenosine cyclic monophosphate (cyclic AMP) and theophylline was studied in water-loaded, alcohol-anaesthetized rats. 2 Lithium reversibly inhibits the antidiuretic response to all concentrations of ADH, depressing the maximum response but not changing the amount required for half maximal response. 3 The rate of increase of serum lithium relates more clearly to the inhibitory effect than does the serum concentration. 4 Sodium concentrations in the renal papilla seem to fall when serum lithium levels are rising. 5 Lithium inhibits the antidiuretic response to ATP and cyclic AMP but does not inhibit the response to theophylline.Keywords
This publication has 14 references indexed in Scilit:
- Interaction of Lithium with Vasopressin-Sensitive Cyclic AMP System of Human Renal MedullaEndocrinology, 1974
- On the Mechanism of Lithium-Induced Diabetes Insipidus in Man and the RatJournal of Clinical Investigation, 1974
- The relationship between the antidiuretic activity of rat eye plexus blood and passive avoidance behaviourPhysiology & Behavior, 1973
- ACUTE EFFECTS OF LITHIUM ON THE ACTION AND RELEASE OF ANTIDIURETIC HORMONE IN RATSActa Endocrinologica, 1973
- Adenyl Cyclase Activity in Kidneys of Rats with Lithium-Induced PolyuriaActa Pharmacologica et Toxicologica, 1972
- The effect of NaCl and LiCl on vasopressin-sensitive adenyl cyclaseLife Sciences, 1970
- Lithium-induced diabetes insipidus-like syndromeComprehensive Psychiatry, 1970
- Action of Alkali Metals on Papillary-Cortical Sodium Gradient Of Dog Kidney.Experimental Biology and Medicine, 1967