PHEOCHROMOCYTOMA IN FATHER AND SON: REPORT OF THE EIGHTH KNOWN AFFECTED KINDRED*

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Abstract
The occurrence of pheochromocytoma of the left adrenal gland in lather and son is described, the eighth kindred with familial pheochromocytoma to be reported. A presentation of the family background and distribution of blood groups within the family is included, with the hope that similar studies on other kindred may make linkage calculations and clarification of the mode of inheritance possible. Further genetic implications of chromaffin-cell tumors are noted, as suugested by the frequent occurrence of pheochromocytoma with neurofibromatosis, the predominance of norepinephrine in chromaffin-cell tumors and the recent findings indicating separate cell origins of norepinephrine and epinephrine.