Reduced 8-aminoquinoline analogues as potential antimalarial agents

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Abstract
The synthesis of 1-alkyl-8-(aminoalkylamino)-6-methyl-1,2,3,4-tetrahydroquinolines, 8-(4''-amino-1''-methylbutylamino)-6-methoxy-1-methyl-1,2-dihydroquinoline, 5-substituted 8-(4''-amino-1''-methylbutylamino)-1-methyl-1,2-dihydroquinolines, 8-alkylamino-1-(2-N,N-diethylaminoethyl)-6-methoxy-1,2,3,4-tetrahydroquinolines, 1-(2-N,N-diethylaminoethyl)-6-methoxy-1,2,3,4-tetrahydroquinoline, 1-(2-N,N-diethylaminoethyl)-8-(2-N,N-diethylaminoethylamino)-6-methoxy-1,2,3,4-tetrahydroquinoline and 2-substituted 8-methoxy-5,6-dihydro-4-imidazo-[i,j]quinolines is described. These compounds and most of the intermediates used in their preparation were tested against Plasmodium berghei in mice and a few compounds were tested for prophylactic activity against P. cynomolgi in rhesus monkeys.

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