Early Growth Response-1 in Cardiovascular Pathobiology
Open Access
- 3 February 2006
- journal article
- review article
- Published by Wolters Kluwer Health in Circulation Research
- Vol. 98 (2) , 186-191
- https://doi.org/10.1161/01.res.0000200177.53882.c3
Abstract
The immediate-early gene product and zinc finger transcription factor early growth response (Egr)-1 plays a key master regulatory role in multiple cardiovascular pathological processes. This article reviews the amassing recent evidence implicating Egr-1 in atherosclerosis, intimal thickening after acute vascular injury, ischemic pathology, angiogenesis, allograft rejection, and cardiac hypertrophy.Keywords
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