Intramembrane Interactions between Neurotensin Receptors and Dopamine D2 Receptors as a Major Mechanism for the Neuroleptic‐like Action of Neurotensina
- 1 October 1992
- journal article
- review article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 668 (1) , 186-204
- https://doi.org/10.1111/j.1749-6632.1992.tb27350.x
Abstract
Evidence has been presented that behavioral actions of NT, inducing its neuroleptic-like action, can be explained on the basis of NT-D2 intramembrane receptor-receptor interactions in the basal ganglia, unrelated to the coexistence phenomenon, leading to reduced affinity and transduction of the D2 agonist binding site. By reducing selectively D2 receptor transduction at the pre- and postsynaptic level, the NT receptor appears capable of switching the DA synapses towards a D1 receptor-mediated transduction, illustrating how receptor-receptor interactions can increase the functional plasticity of central synapses (FIG. 12).Keywords
This publication has 38 references indexed in Scilit:
- Biochemical characterization of the intramembrane interaction between neurotensin and dopamine D2 receptors in the rat brainBrain Research, 1991
- A trypsin inhibitor-like peptide PEC-60 reduces the affinity of dopamine D2 agonist binding sites in rat neostriatal membranesEuropean Journal of Pharmacology: Molecular Pharmacology, 1991
- Changes in pituitary-adrenal activity affect the binding properties of striatal dopamine D-2 receptors but not their modulation by neurotensin and cholecystokinin-8Neurochemistry International, 1990
- Neurotensin Binding to DopamineJournal of Neurochemistry, 1990
- Neurotensin reduces the affinity of dopamine D2 receptors in membranes from post mortem human caudate-putamenNeuroscience Letters, 1990
- Modulation of dopamine D1 receptor binding by neurotensin in the rat striatumNeurochemistry International, 1989
- Neurotensin Stimulates the Phosphorylation of Caudate Nucleus Synaptosomal ProteinsAnnals of the New York Academy of Sciences, 1988
- Further evidence for the existence of interactions between receptors for dopamine and neurotensin. Dopamine reduces the affinity and increases the number of [3H]-neurotensin binding sites in the subcortical limbic forebrain of the ratActa Physiologica Scandinavica, 1985
- Neurotensin stimulates inositol phospholipid hydrolysis in rat brain slicesBrain Research, 1984
- Selective decrease in the affinity of D2 dopamine receptor for agonist induced by islet-activating protein, pertussis toxin, associated with ADP-ribosylation of the specific membrane protein of bovine striatumBiochemical and Biophysical Research Communications, 1983