Glucose-Assimilation und Insulinwirkung bei x-chromosomaler rezessiv erblicher Muskeldystrophie (Typ Duchenne) im Belastungstest

Publisher Website
Google Scholar
Abstract
Studies are reported on 10 young males with progressive muscular dystrophy (inherited recessive x-chromosomal Duchenne form) and on 10 metabolically normal children. There was a significant decrease in the assimilation of glucose or in the activity of insulin, following the parenteral injection of glucose or insulin. The dose/response curves for insulin for healthy subjects and those with muscle dystrophy were prepared and expressed mathematically. A decrease in the utilization of glucose was also found in the combined administration of glucose and insulin, or of glucose and Artosin, and in the Artosin test. The disturbance of glucose utilization was independent of the stage of the illness. The pathological findings were interpreted in the context of a genetically determined metabolic anomaly or a defective insulin-binding mechanism on the cell membrane. A possible therapeutic action of insulin is discussed.

This publication has 2 references indexed in Scilit: