1-Carbamyl-2-Phenylhydrazine Tumorigenesis in Swiss Mice. Morphology of Lung Adenomas2

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Abstract
A solution of 0.25% 1-carbamyl-2-phenylhydrazine was administered daily for life in the drinking water of randomly bred Swiss mice. In the treated animals the incidence of lung tumors was 78% in females and 69% in males, whereas the corresponding incidences in the untreated controls were 21 and 23%, respectively. Light, transmission, and scanning electron microscopic examination of the induced lung lesions revealed adenomas composed of alveolar cells, type B. Ultrastructural characteristics in the cytoplasm included lamellar and osmiophilic bodies, membrane-bound lakelike structures, dense particles, and myelin figures. Free cell surface characteristics were described and illustrated. The results proved, for the first time, the tumorigenicity of this substituted hydrazine which is known to possess antipyretic action.

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