High-dose cisplatin in hypertonic saline in refractory ovarian cancer.

Publisher Website
Google Scholar
Abstract
Nineteen previously treated refractory ovarian cancer patients, including 17 who had received standard-dose cisplatin regimens, were treated in a phase II trial with high-dose cisplatin (40 mg/m2 daily for five days with cycles administered every 28 to 35 adays). Objective responses were achieved in 6/19 (32%) patients while eight patienits had minor responses or stable disease. The median duration of survival from the start of salvage chemotherapy was 12 months for all patients and 16 months for responding patients. The dose-limiting toxicity was peripheral neuropathy with 37% of patients having severe parethesias or ataxia. These results indicatethat the dose of cisplatin may be an important factor in improving survival in ovarian cancer patients.