Molecular Aspects of the Excitation-Contraction Coupling in Skeletal Muscle.
- 1 January 1999
- journal article
- review article
- Published by Physiological Society of Japan in The Japanese Journal of Physiology
- Vol. 49 (4) , 325-333
- https://doi.org/10.2170/jjphysiol.49.325
Abstract
Extremely rapid and massive release of Ca(2+) from the sarcoplasmic reticulum upon depolarization of the T-tubule regulates the contraction of skeletal muscle. The dihydropyridine receptor (voltage sensor) on the T-tubule faces the ryanodine receptor (Ca(2+) release channel) on the sarcoplasmic reticulum at the triadic junction and their intermolecular interaction is responsible for the swift release of Ca(2+) from the sarcoplasmic reticulum. We are now beginning to gain insight into the molecular structures that are important for the coupling mechanism.Keywords
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