The Influence of Sulfonamides on Infectious Otitis Interna. Experiments with Guinea Pigs. Report 2
- 1 January 1947
- journal article
- research article
- Published by Taylor & Francis in Acta Oto-Laryngologica
- Vol. 35 (1-2) , 77-90
- https://doi.org/10.3109/00016484709123265
Abstract
For the purpose of studying the effect of sulfonamides on purulent otitis interna 18 guinea pigs were infected with virulent hemo-lytic streptococci direct into the cochlea, and 12 guinea pigs into the middle ear after preparation with a solution of arsenic trioxidc and hydrochloric acid. Every second animal was treated with prontosil, the others served as controls. The animals were killed 1 to 12 days after infection. Serial sections were made from the infected ears. The investigations revealed that prontosil treatment checked the spread of infection, especially at those points where there were natural obstructions and narrow spaces. Consequently prontosil restricts the spread of infection and lessens the destruction of tissue.Keywords
This publication has 4 references indexed in Scilit:
- On the Treatment of Purulent Otitis Interna with Sulfonamides. Clinical FindingsActa Oto-Laryngologica, 1946
- Die Wirkung der arsenigen Säure auf das OhrPublished by Springer Nature ,1929
- Experimentelle Untersuchungen über Labyrintherkrankung und deren Beziehung zur MeningitisZeitschrift für die gesamte Neurologie und Psychiatrie, 1916
- Experimentelle Studien über die LabyrinthitisPublished by Springer Nature ,1912