Development of High Affinity and High Specificity Inhibitors of Matrix Metalloproteinase 14 through Computational Design and Directed Evolution
Open Access
- 1 February 2017
- journal article
- research article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 292 (8) , 3481-3495
- https://doi.org/10.1074/jbc.m116.756718
Abstract
No abstract availableKeywords
Funding Information
- National Institutes of Health (R01CA154387, R21CA205471)
This publication has 77 references indexed in Scilit:
- Matrix Metalloproteinase-10 (MMP-10) Interaction with Tissue Inhibitors of Metalloproteinases TIMP-1 and TIMP-2Journal of Biological Chemistry, 2012
- Phage Display of Tissue Inhibitor of Metalloproteinases-2 (TIMP-2)Journal of Biological Chemistry, 2011
- Selective inhibition of ADAM12 catalytic activity through engineering of tissue inhibitor of metalloproteinase 2 (TIMP-2)Biochemical Journal, 2010
- The tissue inhibitors of metalloproteinases (TIMPs): An ancient family with structural and functional diversityBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2010
- Tissue Inhibitors of Metalloproteinases in Cell Signaling: Metalloproteinase-Independent Biological ActivitiesScience Signaling, 2008
- Factors determining antibody distribution in tumorsTrends in Pharmacological Sciences, 2008
- Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular diseaseBiochemical Pharmacology, 2008
- Control of matrix metalloproteinase catalytic activityPublished by Elsevier ,2007
- Validating matrix metalloproteinases as drug targets and anti-targets for cancer therapyNature Reviews Cancer, 2006
- New functions for the matrix metalloproteinases in cancer progressionNature Reviews Cancer, 2002