Systemic and Neuropathologic Effects of E. coli Endotoxin in Neonatal Dogs
- 1 May 1983
- journal article
- research article
- Published by Springer Nature in Pediatric Research
- Vol. 17 (5) , 349-353
- https://doi.org/10.1203/00006450-198305000-00008
Abstract
Summary: The acute systemic and neuropathologic effects of E. coli endotoxin were determined in neonatal dogs. Administration of sublethal (LD0), moderate (LD50), or lethal (LD100) doses of endotoxin produced significant arterial hypotension, metabolic (lactic) acidosis, and hypoglycemia. Neuropathologic changes consisted of widespread inflammation in both grey and white matter; however, necrotic lesions were found only in forebrain white matter.Keywords
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