VARIABLE REGION (FV) DETERMINANTS ON MOUSE LYMPHOCYTES

  • 1 January 1976
    • journal article
    • research article
    • Vol. 30  (6) , 841-850
Abstract
Antisera [rabbit] was raised to the Fv fragment derived from a mouse .alpha./.lambda. myeloma. These had different reactivities for Fv and mouse immunoglobulin, and 2 of them appeared to detect v [variable] region framework determinants on normal mouse immunoglobulins. A large proportion of mouse lymphocytes had Fv determinants on the surface which was part of the B[bone marrow-derived]-lymphocyte antigen receptor. Most of the reacting cells were B lymphocytes. Fv determinants were not detected on the majority of T [thymus-derived] lymphocytes, including cells with known T-helper cell activity. In mice, T cells do not express immunoglobulin v region framework determinants on their surface.