Tools for mapping high-throughput sequencing data

Open Access

11 October 2012

journal article
review article
Published by Oxford University Press (OUP) in Bioinformatics

Vol. 28 (24) , 3169-3177
https://doi.org/10.1093/bioinformatics/bts605

Abstract

Motivation: A ubiquitous and fundamental step in high-throughput sequencing analysis is the alignment (mapping) of the generated reads to a reference sequence. To accomplish this task, numerous software tools have been proposed. Determining the mappers that are most suitable for a specific application is not trivial. Results: This survey focuses on classifying mappers through a wide number of characteristics. The goal is to allow practitioners to compare the mappers more easily and find those that are most suitable for their specific problem. Availability: A regularly updated compendium of mappers can be found at http://wwwdev.ebi.ac.uk/fg/hts_mappers/. Contact:nf@ebi.ac.uk Supplementary information: Supplementary data are available at Bioinformatics online.

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