Endoscopic Sclerotherapy for Bleeding Esophageal Varices: Effects and Complications

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Abstract
Endoscopic esophageal vein sclerosis recently was revived as a treatment for bleeding varices because long-term results with portacaval shunts were poorer than suggested by initial short-term studies. Esophageal vein thrombosis secondary to endothelial damage was considered the result of the activity of the sclerosing agents, but until 1981 there was little pathologic documentation. Autopsy findings in 10 patients who died after variceal sclerosis suggest that variceal obliteration is achieved by mural necrosis followed by fibrosis, and that thrombosis is only a transient phenomenon. Complications of sclerotherapy that were found included ulceration, hemorrhage, perforation and stricture.

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