Viral Load and Response to Treatment of HIV

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Abstract
The interesting article by O'Brien et al. (Feb. 15 issue)1 has several shortcomings. When measurements corresponding to the same time points are not available for all patients in a study, patients with samples obtained early after the start of antiretroviral therapy tend to have higher observed average reductions in human immunodeficiency virus (HIV) RNA than patients from whom samples were mostly obtained later; their actual responses may be different.