A proposition for long-term biocompatibility test of dental materials in vitro

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Abstract
The importance of establishing a testing method for long-term biocompatibility of dental materials can not be overemphasized, since the materials remain in the living system for a long period of time once inserted. Unfortunately, the current testing methods lay greater stress on shorter testing periods than on longer ones. In addition, none of them include testing in an environment simulating the oral cavity. The present study incorporated to some degrees these two essential factors, i.e. long-term test and oral simulation. Standardization of each step was made and satisfactory results were obtained.

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