Reduction of fertility of mice by the intrauterine injection of prostaglandin antagonists
- 1 November 1981
- journal article
- research article
- Published by Bioscientifica in Reproduction
- Vol. 63 (2) , 365-372
- https://doi.org/10.1530/jrf.0.0630365
Abstract
The intrauterine injection of 7-oxa-13-prostynoic acid, 18,18,20-trimethyl PGE-2 and meclofenamic acid in mice at the expected times of implantation significantly reduced the number of implantation sites. Indomethacin was ineffective possibly because it was exposed to high pH during the preparation of the solutions for injection. These prostaglandin antagonists may exert their antifertility action at multiple sites involving both the embryo and mother.This publication has 4 references indexed in Scilit:
- Inhibition of hatching of mouse blastocysts in vitro by various prostaglandin antagonistsReproduction, 1981
- Prostaglandins and Increased Endometrial Vascular Permeability Resulting from the Application of an Artificial Stimulus to the Uterus of the Rat Sensitized for the Decidual Cell Reaction1Biology of Reproduction, 1979
- The concentration of 6-keto-prostaglandin F1α is markedly elevated at the site of blastocyst implantation in the ratProstaglandins, 1978
- Effects of indomethacin on uterine capillary permeability and blastocyst development in rabbitsProstaglandins, 1978