Phosphoglucomutase 3: Formal and Population Genetics and Observations on Abnormal Phenotypes1
- 1 November 1975
- journal article
- Published by Wiley in Vox Sanguinis
- Vol. 29 (5) , 363-370
- https://doi.org/10.1111/j.1423-0410.1975.tb00520.x
Abstract
514 healthy blood donors and 47 families with 122 offspring were studied for phosphoglucomutase 3 (PGM3) from leukocytes. There was a good agreement of allelic frequencies obtained compared to those reported previously in Caucasians. In addition, three individuals with abnormal phenotypes were observed: one was a patient with Hodgkin's disease, the other two were apparently healthy blood donors. In two cases, family members could be studied; none carried the abnormal type of the father. The possible background of these observations with respect to the attachment of the PGM3 locus to the immunogenetic linkage group--the major histocompatibility complex--on chromosome No. 6 in man is discussed.Keywords
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