A SepPak® HPLC Method for Tricyclic Antidepressant Drugs in Human Vitreous Humor
- 1 November 1989
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Analytical Toxicology
- Vol. 13 (6) , 322-325
- https://doi.org/10.1093/jat/13.6.322
Abstract
Death from tricyclic antidepressant overdose has become an all-too-common occurrence. Several factors, including postmortem concentration changes, can render blood and tissue samples useless for the determination of antidepressant drug concentrations. We present here an efficient method of solid-phase extraction for these drugs from vitreous humor and a reversed-phase, isocratic high-performance liquid chromatographic method for the simultaneous quantitation of amitriptyline, doxepin, and imipramine and their desmethylated metabolites.This publication has 9 references indexed in Scilit:
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