Living related kidney donors (62) were nephrectomized during a 10 yr period. The overall complication rate was 40%, most complications being minor. Among the major complications was 1 patient with pulmonary embolism and 3 patients with hepatitis. One female donor suffered a psychoneurotic reaction following rejection of the donated kidney and she is still away from work more than 2 yr later. The other 61 donors were back to work within 2-18 (mean 8) wk. The mean serum creatinine levels increased from 0.95 preoperatively to 1.15 mg/100 ml at the followup examination, which took place between 6 mo. and 9 yr after nephrectomy. The mean increase in serum creatinine was higher in donors above 50 yr of age (P < 0.02). The mean creatinine clearance of the whole group decreased from 111 to 90 ml/min. The mean increase in size of the remaining kidney was 22%. Donor nephrectomy was a safe procedure with few serious complications and the prognosis for the recipient was excellent. Transplantation from a family member was the treatment of choice in terminal uremia.