Nucleotide and deduced amino acid sequence of human cysteinyl-tRNA synthetase
- 1 January 1994
- journal article
- research article
- Published by Taylor & Francis in DNA Sequence
- Vol. 4 (4) , 243-248
- https://doi.org/10.3109/10425179409020847
Abstract
We have determined the nucleotide sequence of a cDNA coding human cysteinyl-tRNA synthetase. The predicted protein sequence of 638 amino acids has substantial sequence similarity to the E. coli cysteinyl-tRNA synthetase in the nucleotide-binding fold region that constitutes the potential active site. The results are consistent with the hypothesis that evolution of the full complement of aminoacyl-tRNA synthetases occurred prior to the divergence of prokaryotes and eukaryotes.Keywords
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