Comparative analysis of copy number detection by whole-genome BAC and oligonucleotide array CGH
Open Access
- 29 June 2010
- journal article
- Published by Springer Nature in Molecular Cytogenetics
- Vol. 3 (1) , 11
- https://doi.org/10.1186/1755-8166-3-11
Abstract
Microarray-based comparative genomic hybridization (aCGH) is a powerful diagnostic tool for the detection of DNA copy number gains and losses associated with chromosome abnormalities, many of which are below the resolution of conventional chromosome analysis. It has been presumed that whole-genome oligonucleotide (oligo) arrays identify more clinically significant copy-number abnormalities than whole-genome bacterial artificial chromosome (BAC) arrays, yet this has not been systematically studied in a clinical diagnostic setting.Keywords
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