HORMONAL CONTROL OF ZINC IN MATURE RAT TESTIS

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Abstract
SUMMARY: Eleven days following hypophysectomy the capacity of the rat testis to take up administered 65Zn is markedly depressed below values noted in intact controls, even though microscopically there is only a slight diminution in the number of germinal epithelial and interstitial elements. Interstitial cell-stimulating hormone (ICSH) in doses of 5 μg./day administered from the 5th to the 10th day after operation completely prevented the fall in total 65Zn uptake of the testis following removal of the pituitary. Follicle stimulating hormone (FSH) was less effective than ICSH in this regard. The possibility of the FSH effect being due to contamination with ICSH is considered. Growth hormone and prolactin in doses of 200 μg./day administered from the 5th to 10th day after operation were ineffective in preventing the fall in 65Zn uptake of the testis following hypophysectomy.