THE OCULAR MANIFESTATIONS OF ARIBOFLAVINOSIS

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Abstract
In a recent communication we presented observations on ocular changes noted in a small group of patients with ariboflavinosis.1Slit lamp examination showed that a superficial vascularizing keratitis was the principal ocular manifestation. The corneal lesions and associated symptoms and signs disappeared during the administration of riboflavin and recurred when it was withdrawn. The present report deals with observations made on forty-seven persons shown to be receiving insufficient riboflavin. Several presented no labial or lingual signs of ariboflavinosis but had definite ocular changes which resolved during treatment with the vitamin. The nine patients mentioned in our preliminary report are included in this series. SUBJECTS The patients studied fell into three groups: Sixteen were hospitalized for nutritional disease, and of these eleven had pellagra or were known to have had typical pellagrous lesions within a year. Thirteen were outpatients; three of these were pellagrins in whom signs of ariboflavinosis developed

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